Pacquiao has not fought since his win over Keith Thurman in July 2019.
The legendary Filipino is now 42 years old and boasts a record of 62 wins from his 71 professional fights.
But he is still eager to mix it at the highest level and is now set to face the dangerous Spence Jr – 11 years Pacquiao’s junior – in Las Vegas this summer.
‘The Truth’ has enjoyed a perfect run as a pro thus far and beat Danny Garcia in Texas in December to retain his welterweight gold.
Pacquiao v Spence: Date and how to watch
This 12-round welterweight title bout will take place on Saturday, August 21 and is being held at the T-Mobile Arena in Las Vegas.
The ring walks for Pacquiao v Spence are expected from 5am on Sunday morning UK time.
No TV coverage has been confirmed for the UK as of yet but the fight will be shown on FOX PPV in the USA.
Pacquiao v Spence: Undercard
MORE TO FOLLOW
- MAIN EVENT: Manny Pacquiao v Errol Spence Jr – for WBC and IBF welterweight titles
- Yordenis Ugas v TBA – for WBA super-welterweight title
Pacquiao v Spence: What’s been said?
Undisputed light-welterweight champion Josh Taylor fears idol Manny Pacquiao may well come unstuck against a ‘young, fresh and hungry’ Errol Spence Jr.
“Spence is big for the weight, really big for welterweight,” Taylor told talkSPORT.
“He is huge, a really big lad, so I think he might be a bit too big for Pacquiao and young and fresh and hungry.
“So I think it might be a bit of a step too far for Pacquiao.
“But I’ve watched him training recently and videos of him, he looks like he has rolled back the years! He looks like he has got sharper and faster as 40 old year-old!
“It’s unbelievable; he is still doing it and he is an absolute living legend of the sport.”